Services offered for all
Bone Marrow / Stem Cell Transplantation
What is Bone Marrow Transplant, or Haematopoietic Stem Cell Transplant?
Bone marrow transplantation is a procedure wherein stem cells from bone marrow that produce various blood cells like red blood cells, white blood cells and platelets are injected into aecipient. These stem cells are also referred to as hematopoietic stem cells. Nowadays, hematopoietic stem cells may also be obtained from peripheral blood after treatment with certain growth factors or from an umbilical cord. Thus, the term ‘Hematopoietic stem cell transplantation` is now preferred to ‘Bone marrow transplantation` to include these other sources of hematopoietic stem cells.
The bone marrow is a soft, spongy portion within a bone. It contains immature cells called stem cells that have a continuous ability to produce different types of blood cells i.e. red blood cells, white blood cells and platelets. These are then released into the blood stream. Bone marrow is of two types, red marrow and yellow marrow. In children, most of the marrow is red marrow and is rich in stem cells. In adults, however, a large portion of the bone marrow is converted into yellow marrow due to infiltration of fat cells. Red marrow in adults is usually restricted to a few
bones like the hip bones, breast bone, ribs, shoulder blades, skull, backbone, and the ends of the arm and thigh bones.
BMT/HSCT is offered for:
Benign Hematological Disorders: Thalassemia, Sickle Cell Disease, Aplastic Anemia, Bleeding Disorders, Coagulation Disorders, etc.
Malignant Hematological Disorders: Acute and Chronic Leukemia (AML/ALL/CML/CLL), Hodgkins and Non-Hodgkins Lymphoma, Multiple Myeloma, Myelodysplasia (MDS), etc.
BMT actually means infusion of stem cells (collected either from bone marrow or peripheral blood or cord blood) into the recipient. The type of bone marrow that is used for the transplant distinguishes the different types of BMT.
Types of BMT
There are three main phases to the BMT process:
Although the experience during these phases may be quite different for each patient, we shall describe a general overview here.
Transplant Treatment Process
The journey of a patient through a transplant is divided into seven steps. Beginning with preparing
for the journey, the steps tell you what to expect along the way.
1. Preparation: The preparation phase begins when the patient arrives at the treatment center and begins the process of medical evaluation, orientation, informed consent, and other preliminary activities. a. Beginning Medical Evaluation
2. Bone-Marrow/Stem Cells Harvest: Collection of the stem cells from either the bone marrow or peripheral blood by apheresis, from either the donor (in Allogenic transplant) or from the patient itself (in Autologus transplant).
3. Conditioning: The conditioning phase begins thea ctualtrans plant process. Durin gthis phase, high-dose chemotherapy,radiation therapy, or both are initiated. Chemotherapy and radiation therapy are given in doses that obliterate the marrowfunction and result in the greatestpossibility of destroying the disease.Depending upon the chemotherapy agentsand radiation therapy administrationschedule, some conditioning therapy canbe administered in the outpatient setting,thus potentially shortening the inpatient stay. The Preparation, Harvest andConditioning together comprise thePre-BMT Phase.
4. Transplant: The transplant phase is the infusion ofdonor bone marrow or stem cells. After the conditioning regimen is completed, thepatient receives the infusion of bonemarrow or stem cells. The duration beyondthe transplant day is considered as thePost BMT phase.
5. Waiting for Engraftment: This phase includes close monitoring,supportive treatment, and management ofcomplications while waiting for signs ofengraftment (new cell growth).
6. Engraftment and Early Recovery: Approximately 10 to 28 days aftertransplant, signs that the new bonemarrow or stem cells are engrafting(growing and developing) can be expected.Close monitoring will continue along withsupportive care. Preparation for the returnof the patient to the referring physician or center will begin.
7. Long-Term Recovery: The long-term recovery phase involvesleaving the treatment center, dealing with any ongoing clinical issues, andre-establishing life patterns. Patientshowever need to follow up for any longterm complications of BMT.
The Nanavati Centre for Bone Marrow Transplant is part ofNanavati Super Speciality Hospital - one of India`s largest, private sector, tertiary care hospitals. The centre`s aim is toprovide patients with incurable blood disorders the option of transplant as a possible cure.
Nanavati`s team has a combined experience of around 500 transplants. More than 300 transplants have been performed by the team within a short span of 4 years, at a success rate of over 80%, which is at par with the world`s best.
The centre attracts transplant patients not only from India, but also from countries like Iraq, Pakistan, Afghanistan, Nigeria, Kenya, Sudan, United Arab Emirates, Uzbekistan and Nepal.
State of the art Infrastructure
The Centre is equipped with ultra-modern infrastructure and an internationally trained, widely experienced faculty. It is supported by state-of-the-art laboratory & transfusion services, along with a fully-equipped radiation oncology unit, with facilities for total body irradiation.
The center is also an authorized stem cell collection center for DATRI Blood Stem Cell Donor`s Registery.
Centre`s key features include:
Department of Transfusion Medicine
A Full Service Offering
The Centre diagnoses and treats a wide variety of blood disorders and blood cancers, such as all kinds of anemia, marrow failure syndromes, coagulation disorders, acute and chronic leukemia, myelomas, lymphomas and myeloproliferative& lymphoproliferative disorders.
Its range of facilities and services include both Allogenic and Autologous transplant using bone marrow, peripheral blood stem cells and cord blood stem cells for various benign and malignant disorders.
The following types of transplants are performed at the centre: