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Allogeneic Transplant

The Allogeneic Transplant Unit is a part of the Centre for Haematology & Bone Marrow Transplant at Nanavati Super Speciality Hospital. It is a fully integrated unit providing comprehensive medical, diagnostic, and surgical services to patients suffering from a broad range of diseases, including malignant diseases such as leukaemias and lymphomas, non-malignant diseases such as aplastic anaemia, and a variety of inherited diseases.

Our team of skilled haematologists and transplant physicians provide optimum patient care by following a multidisciplinary strategy to create a patient-centric treatment plan that is designed keeping in mind the unique needs of each patient.

The unit is well- equipped with state-of-the-art treatment facilities offering advanced technology and latest therapies to treat most of the complex conditions requiring allogeneic transplantation. We strive to provide comprehensive, compassionate, and personalised care to each patient under our care thereby improving their quality of life.

During an Allogeneic transplant, the stem cells for transplantation are collected from a matching donor and transplanted into the patient’s body after high-intensity chemotherapy or radiation. The donor can be a sibling, a relative, or an unrelated person who is a Histocompatible Leukocyte antigen (HLA) match. An Allogeneic transplant can be streamlined as:

Types of Allogeneic Bone Marrow Transplant:

  • HLA (immune)-Match Related Donor (Siblings) Transplant: The bone marrow or stem cells come from the relative of a patient, who is usually a sibling (brother or sister) who's HLA (Histocompatible Leukocyte antigen) matches completely with the patient.
  • HLA (immune)-Matched Unrelated Donor Transplant: The bone marrow or stem cells come from an unrelated donor whose HLA (Histocompatible Leukocyte antigen) matches completely with the patient.
  • Haplo Identical Donor Transplant: The bone marrow or stem cells comes from HLA (Histocompatible Leukocyte antigen) half-matched (haplotype) donors such as biological parents of the patient or half-matched siblings.
  • Umbilical Cord Blood Transplant: Umbilical cord blood cells are collected from a newborn child’s umbilical cord right after birth. These stem cells are very immature so the need for perfect matching is eliminated. The stem cells collected from the cord are frozen and stored until they are used for a transplant.

Allogeneic Transplant Procedure

  • The Donor is given medicines to boost stem cells counts in the blood
  • Stem cells are collected from the donor’s blood
  • Patient undergoes conditioning process where they receive high doses of chemotherapy with or without radiation therapy.
  • Infusion of donor’s stem cells into the patient’s bloodstream (where they travel to the bone marrow to create new cells)
  • Patient must remain in close monitoring and medical care for few days after which they are discharged and is ready to go home.

There are various serious health conditions which require allogeneic transplant as a cure. Such illnesses include:

Non-malignant diseases

  • Hemoglobinopathies
    • Beta-thalassemia major
    • Sickle cell disease
  • Bone Marrow Failure States, including:
    • Severe aplastic anaemia
    • Fanconi’s anaemia
    • Paroxysmal nocturnal hemoglobinuria (PNH)
    • Pure red cell aplasia: Acquired and inherited (DBA)
    • Amegakaryocytosis / congenital thrombocytopenia
  • Immunodeficiency states
    • Severe combined immunodeficiency (SCID)
    • Wiskott-Aldrich syndrome
    • Chediak-Higashi syndrome
    • Congenital neutropenia
  • Metabolic disorders
    • Hurler's syndrome (MPS-IH)
    • Adrenoleukodystrophy
    • Metachromatic leukodystrophy
    • Gaucher’s disease
    • Nieman picks a disease
    • Osteopetrosis

Malignant diseases

  • Acute myelogenous leukaemia (AML)
  • Myelodysplastic Syndrome (MDS)
  • Acute lymphoblastic leukaemia (ALL)
  • Juvenile myelomonocytic leukaemia (JMML)
  • Chronic myelogenous leukaemia (CML)
  • Chronic Lymphocytic Leukemia (CLL)
  • Myeloproliferative disorders: Myelofibrosis

Find Complete Relief from Nanavati Experts

If you think you are facing similar conditions, or have suffered from them in the past, please contact the Nanavati team to schedule an appointment at : +91 22 2626 7500

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